Introduction：Basic information about L-Menthyl acetate CAS 2623-23-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Menthyl acetate Basic information
| Product Name: | L-Menthyl acetate |
| Synonyms: | 2-isopropyl-5-methyl-,acetate,l-cyclohexan-1-o;5-methyl-2-(1-methylethyl)-,acetate,[1R-(1.alpha.,2.beta.,5.alpha.)]-Cyclohexanol;acetate,(1r,3r,4s)-(-)-mentho;MENTHYL ACETATE, L-;L-MENTHYL ACETATE;FEMA 2668;(-)-ACETOXY-P-MENTHANE;(-)-(1R)-MENTHYL ACETATE |
| CAS: | 2623-23-6 |
| MF: | C12H22O2 |
| MW: | 198.3 |
| EINECS: | 220-076-0 |
| Product Categories: | Pharmaceutical Raw Materials;Esters;Chiral Building Blocks;EstersAlphabetic;M;MEA - MES;Organic Building Blocks;Monocyclic Monoterpenes;Biochemistry;Terpenes |
| Mol File: | 2623-23-6.mol |
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L-Menthyl acetate Chemical Properties
| Melting point | <25 °C |
| alpha | -81°(20/D, c=8, C6H6) |
| Boiling point | 229-230 °C(lit.) |
| density | 0.92 g/mL at 25 °C(lit.) |
| vapor pressure | 45Pa at 20℃ |
| refractive index | n20/D 1.447(lit.) |
| FEMA | 2668 | MENTHYL ACETATE (ISOMER UNSPECIFIED) |
| Fp | 171 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Colourless |
| Specific Gravity | 0.922 |
| Odor | at 100.00 %. mentholic minty herbal tea fruity woody floral earthy |
| Odor Type | mentholic |
| Optical Rotation | [α]20/D 81°, c = 8 in benzene |
| Water Solubility | 23.2mg/L at 20℃ |
| Merck | 14,5839 |
| JECFA Number | 431 |
| BRN | 2208505 |
| Major Application | flavors and fragrances |
| InChI | 1S/C12H22O2/c1-8(2)11-6-5-9(3)7-12(11)14-10(4)13/h8-9,11-12H,5-7H2,1-4H3/t9-,11+,12-/m1/s1 |
| InChIKey | XHXUANMFYXWVNG-ADEWGFFLSA-N |
| SMILES | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O |
| LogP | 4.39 at 25℃ |
| CAS DataBase Reference | 2623-23-6(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)- (2623-23-6) |
Safety Information
| Safety Statements | 24/25 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| RTECS | AI5900000 |
| TSCA | TSCA listed |
| HS Code | 2915 39 00 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Aquatic Chronic 2 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
L-Menthyl acetate Usage And Synthesis
| Chemical Properties | (1R)-(-)-Menthyl acetate occurs in peppermint oils. It is a colorless liquid with a fresh, fruity,peppermint odor.
(?)-Menthyl acetate is prepared by acetylation of (?)-menthol (e.g., with aceticanhydride). It is used mainly in peppermint flavors and reconstituted peppermintoils, but also to a small extent in perfumery. |
| Uses | L-Menthyl Acetate, and its derivatives, is used as a penetration enhancers, to enhance the skin permeation of various drugs with differing lipophilicities, such as 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU), isosorbide dinitrate (ISDN), lidocaine (LD), etc. |
| Definition | ChEBI: (-)-Menthyl acetate is a p-menthane monoterpenoid. |
| Flammability and Explosibility | Not classified |
| Biochem/physiol Actions | Taste at 25 ppm |
| Safety Profile | Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. |
| Synthesis | L-Menthyl acetate is produced by direct esterification of racemicMenthol with Acetic acid under azeotropicconditions. |
L-Menthyl acetate Preparation Products And Raw materials
| Raw materials | Sodium acetate-->Peppermint oil |
