CAS 446022-33-9|Pelitrexol

Introduction：Basic information about CAS 446022-33-9|Pelitrexol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pelitrexol BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Pelitrexol
CAS Number	446022-33-9	Molecular Weight	463.507
Density	1.6±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₀H₂₅N₅O₆S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-((5-(2-((6S)-2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)-L-glutamic acid
Synonym	More Synonyms

Pelitrexol BiologicalActivity

Description	Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cancer
Target	GARFT[1]
References	[1]. Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19(13):2665-2680.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Molecular Formula	C₂₀H₂₅N₅O₆S
Molecular Weight	463.507
Exact Mass	463.152557
PSA	215.74000
LogP	-0.58
Index of Refraction	1.743
InChIKey	QXOPTIPQEVJERB-JQWIXIFHSA-N
SMILES	Cc1cc(C(=O)NC(CCC(=O)O)C(=O)O)sc1CCC1CNc2nc(N)[nH]c(=O)c2C1

Synonyms

L-Glutamic acid, N-[[5-[2-[(6S)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methyl-2-thienyl]carbonyl]-

N-[(5-{2-[(6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}-4-methyl-2-thienyl)carbonyl]-L-glutamic acid

(2S)-2-(((5-(2-((6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido(2,3-D)pyrimidin-6-yl)ethyl)-4-methylthiophen-2-yl)carbonyl)amino)pentanedioic acid

Ag2037

Pelitrexol

Unii-dht6E8m4kp

L-Glutamic acid,N-((5-(2-((6S)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)

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