Introduction：Basic information about CAS 131179-95-8|Efaproxiral, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Efaproxiral |
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| CAS Number | 131179-95-8 | Molecular Weight | 341.40100 |
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| Density | 1.202g/cm3 | Boiling Point | 554.5ºC at 760mmHg |
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| Molecular Formula | C20H23NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 289.2ºC |
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Names
| Name | 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid |
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| Synonym | More Synonyms |
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Efaproxiral BiologicalActivity
| Description | Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
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| References | [1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784. |
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Chemical & Physical Properties
| Density | 1.202g/cm3 |
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| Boiling Point | 554.5ºC at 760mmHg |
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| Molecular Formula | C20H23NO4 |
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| Molecular Weight | 341.40100 |
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| Flash Point | 289.2ºC |
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| Exact Mass | 341.16300 |
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| PSA | 75.63000 |
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| LogP | 3.79960 |
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| Vapour Pressure | 3.93E-13mmHg at 25°C |
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| Index of Refraction | 1.597 |
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| InChIKey | BNFRJXLZYUTIII-UHFFFAOYSA-N |
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| SMILES | Cc1cc(C)cc(NC(=O)Cc2ccc(OC(C)(C)C(=O)O)cc2)c1 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2-Dacmpp |
| Efaproxyn |
| 2-[4-((((3,5-dimethylphenyl)-amino)carbonyl)methyl)phenoxy]-2-methyl propionic acid |
| RSR13 |
| 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid |
| Efaproxiral |
| 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid |
| Efaproxiral Sodium |
