CAS 13803-65-1|Anhydrotetracycline Hydrochloride
Introduction：Basic information about CAS 13803-65-1|Anhydrotetracycline Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Anhydrotetracycline Hydrochloride | ||
|---|---|---|---|
| CAS Number | 13803-65-1 | Molecular Weight | 462.880 |
| Density | / | Boiling Point | 618.6ºC at 760 mmHg |
| Molecular Formula | C22H23ClN2O7 | Melting Point | 222.8ºC |
| MSDS | USA | Flash Point | 327.9ºC |
Names
| Name | anhydrotetracycline hydrochloride |
|---|---|
| Synonym | More Synonyms |
Anhydrotetracycline Hydrochloride BiologicalActivity
| Description | Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=210 μM),Tet(X) (IC50=41 μM), Tet(X)_3 (IC50=3 μM) degradations of tetracyclines. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=210 μM),Tet(X) (IC50=75 μM), Tet(X)_3 (IC50=26 μM) degradations of chlortetracycline. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=120 μM),Tet(X) (IC50=41 μM), Tet(X)_3 (IC50=7 μM) degradations of demeclocycline[1]. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=210 μM),Tet(X) (IC50=41 μM), Tet(X)_3 (IC50=3 μM) degradations of tetracyclines. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=210 μM),Tet(X) (IC50=75 μM), Tet(X)_3 (IC50=26 μM) degradations of chlortetracycline. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC50=120 μM),Tet(X) (IC50=41 μM), Tet(X)_3 (IC50=7 μM) degradations of demeclocycline[1]. |
| References | [1]. Jana L Markley, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633. |
Chemical & Physical Properties
| Boiling Point | 618.6ºC at 760 mmHg |
|---|---|
| Melting Point | 222.8ºC |
| Molecular Formula | C22H23ClN2O7 |
| Molecular Weight | 462.880 |
| Flash Point | 327.9ºC |
| Exact Mass | 462.119385 |
| PSA | 161.39000 |
| LogP | 1.95810 |
| Vapour Pressure | 3.66E-16mmHg at 25°C |
| InChIKey | SPFAOPCHYIJPHJ-WPJNXPDPSA-N |
| SMILES | CC1=C2C=CC=C(C2=C(C3=C1C[C@H]4[C@@H](C(=O)C(=C([C@]4(C3=O)O)O)C(=O)N)N(C)C)O)O.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | R63 |
| Safety Phrases | S36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 1702190000 |
Customs
| HS Code | 1702190000 |
|---|
Articles30
More Articles| Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing. Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012) Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate... | |
| Tetracycline repressor allostery does not depend on divalent metal recognition. Biochemistry 53(50) , 7990-8, (2014) Genes that render bacteria resistant to tetracycline-derived antibiotics are tightly regulated by repressors of the TetR family. In their physiologically relevant, magnesium-complexed form, tetracycli... | |
| Use of mCherry Red fluorescent protein for studies of protein localization and gene expression in Clostridium difficile. Appl. Environ. Microbiol. 81(5) , 1652-60, (2015) Fluorescent proteins are powerful reporters in biology, but most require O2 for chromophore maturation, making them inherently difficult to use in anaerobic bacteria. Clostridium difficile, a strict a... |
Synonyms
| (4S,4aS,12aS)-4-(DiMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride |
| (4S,4aS,12aS)-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-2-tetracenecarboxamide hydrochloride (1:1) |
| Anhydrotetracycline hydrochloride,'can be used as secondary standard.' |
| (4S,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE |
| (4aS)-4c-Dimethylamino-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-(4ar,12ac)-1,4,4a,5,12,12a-hexahydro-naphthacen-2-carbonsaeure-amid,Hydrochlorid |
| Anhydrotetracycline hydrochloride,‘can be used as a secondary standard‘ |
| 5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, (4S,4aS,12aS)-, hydrochloride (1:1) |
| Anhydrotetracycline hydrochloride |
| 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,monohydrochloride,(4S,4aS,12aS) |
| AnhydrotetracyclineHCl |
| Anhydrotetracycline hydrochloride,'can be used as a secondary standard' |
| (4aS)-4c-dimethylamino-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-(4ar,12ac)-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide,hydrochloride |
| MFCD00151453 |
