CAS 36839-55-1|Iodo-PEG3-Iodide
| Common Name | Iodo-PEG3-Iodide | ||
|---|---|---|---|
| CAS Number | 36839-55-1 | Molecular Weight | 369.96700 |
| Density | 2.028 g/mL at 25 °C(lit.) | Boiling Point | 293.5ºC at 760 mmHg |
| Molecular Formula | C6H12I2O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | >230 °F |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1,2-Bis(2-iodoethoxy)ethane |
|---|---|
| Synonym | More Synonyms |
Iodo-PEG3-Iodide BiologicalActivity
| Description | 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs |
| In Vitro | 1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1]. |
| References | [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. |
Chemical & Physical Properties
| Density | 2.028 g/mL at 25 °C(lit.) |
|---|---|
| Boiling Point | 293.5ºC at 760 mmHg |
| Molecular Formula | C6H12I2O2 |
| Molecular Weight | 369.96700 |
| Flash Point | >230 °F |
| Exact Mass | 369.89300 |
| PSA | 18.46000 |
| LogP | 1.88960 |
| Index of Refraction | n20/D 1.572(lit.) |
| InChIKey | BCAGFJXMCZSAHD-UHFFFAOYSA-N |
| SMILES | ICCOCCOCCI |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2909199090 |
Customs
| HS Code | 2909199090 |
|---|---|
| Summary | 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| Ethylene Glycol Bis(2-iodoethyl) Ether |
| 1,2-BIS(2-IODOETHOXY)ETHANE |
| MFCD00075008 |
