CAS 6138-79-0|Triprolidine hydrochloride

Introduction：Basic information about CAS 6138-79-0|Triprolidine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Triprolidine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles29
7. Synonyms

Common Name	Triprolidine hydrochloride
CAS Number	6138-79-0	Molecular Weight	314.85200
Density	/	Boiling Point	462ºC at 760 mmHg
Molecular Formula	C₁₉H₂₅ClN₂O	Melting Point	115-120ºC
MSDS	ChineseUSA	Flash Point	233.2ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	triprolidine hydrochloride monohydrate
Synonym	More Synonyms

Triprolidine hydrochloride BiologicalActivity

Description	Triprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria[2].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor
Target	H1 Receptor
In Vivo	Triprolidine (intraseptal infusion; 0.5 μM in 0.5 μl; 30, 60, and 180 min after tetanus) had no significant effects on the baseline fEPSPs, however, it is followed by a smaller Long-term potentiation (LTP) induced during walking (173% of the baseline at 60 min) compared with saline infusion (208% at 60 min) in rats[2]. Animal Model: Adult male Long–Evans TMN (tuberomammillary nucleus (TMN) neurons) lesion rats[2] Dosage: 0.5 μm in 0.5 μl Administration: Intraseptal infusion; 30, 60, and 180 min after tetanus Result: Attenuated the walking-associated enhancement of LTP.
References	[1]. Tao Luo, et al. Endogenous Histamine Facilitates Long-Term Potentiation in the Hippocampus During WalkingJ Neurosci. 2010 Jun 9;30(23):7845-52. [2]. Sang-Chul Shin, et al. Controlled Release of Triprolidine Using Ethylene-Vinyl Acetate Membrane and Matrix Systems. Eur J Pharm Biopharm

Chemical & Physical Properties

Boiling Point	462ºC at 760 mmHg
Melting Point	115-120ºC
Molecular Formula	C₁₉H₂₅ClN₂O
Molecular Weight	314.85200
Flash Point	233.2ºC
Exact Mass	314.15500
PSA	16.13000
LogP	4.65740
InChIKey	WYUYEJNGHIOFOC-NWBUNABESA-N
SMILES	Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl
Storage condition	2-8°C
Stability	Stable, but discolours in light. Incompatible with strong oxidizing agents.
Water Solubility	>=10 g/100 mL at 20 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT7658000

CHEMICAL NAME :: Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, monohydrate, stereoisomer

CAS REGISTRY NUMBER :: 6138-79-0

LAST UPDATED :: 199803

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H22-N2.Cl-H.H2-O

MOLECULAR WEIGHT :: 332.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCTR** National Center for Toxicology Research Technical Report. Office of Associate Director for Scientific Coordination, Jefferson, Arkansas 72079 Volume(issue)/page/year: #414/415,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 163 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCTR** National Center for Toxicology Research Technical Report. Office of Associate Director for Scientific Coordination, Jefferson, Arkansas 72079 Volume(issue)/page/year: #414/415,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10760 mg/kg/90D-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Gastrointestinal - changes in structure or function of salivary glands Blood - changes in leukocyte (WBC) count

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,359,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 103 gm/kg/2Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,223,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 gm/kg/2Y-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NCTR** National Center for Toxicology Research Technical Report. Office of Associate Director for Scientific Coordination, Jefferson, Arkansas 72079 Volume(issue)/page/year: #414/415,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2762 No. of Facilities: 269 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 4419 (estimated) No. of Female Employees: 2546 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT7658000

Articles29

Involvement of histaminergic inputs in the jaw-closing reflex arc.

J. Neurophysiol. 113 , 3720-35, (2015)

Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in cont...

Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.

Biomed. Chromatogr. 29(3) , 465-74, (2015)

The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The l...

Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography.

J. Pharm. Biomed. Anal. 43(1) , 293-7, (2007)

An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a rever...

Synonyms

MFCD00150574

Triprolidine hydrochloride

Recommended......