CAS 313553-47-8|INH1

Introduction：Basic information about CAS 313553-47-8|INH1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. INH1 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	INH1
CAS Number	313553-47-8	Molecular Weight	308.40
Density	1.2±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₈H₁₆N₂OS	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide,hydrochloride
Synonym	More Synonyms

INH1 BiologicalActivity

Description	INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1]Target: Hec1 inhibitorTreating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently leading to metaphase chromosome misalignment, spindle aberrancy, and eventual cell death. INH1 effectively inhibited the proliferation of multiple human breast cancer cell lines in culture (GI(50), 10-21 micromol/L). Furthermore, treatment with INH1 retarded tumor growth in a nude mouse model bearing xenografts derived from the human breast cancer line MDA-MB-468, with no apparent side effects. This study suggests that the Hec1/Nek2 pathway may serve as a novel mitotic target for cancer intervention by small compounds.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cancer
References	[1]. Wu G, et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15;68(20):8393-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₈H₁₆N₂OS
Molecular Weight	308.40
PSA	73.72000
LogP	5.24
Index of Refraction	1.657
InChIKey	JPMOKRWIYQGMJL-UHFFFAOYSA-N
SMILES	Cc1ccc(-c2csc(NC(=O)c3ccccc3)n2)c(C)c1
Storage condition	Desiccate at +4°C

Synonyms

Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-

N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]benzamide

Y0392

INH1

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

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