Introduction：Basic information about CAS 361-09-1|sodium cholate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | sodium cholate |
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| CAS Number | 361-09-1 | Molecular Weight | 430.553 |
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| Density | / | Boiling Point | 583.9ºC at 760 mmHg |
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| Molecular Formula | C24H40NaO5 | Melting Point | 198ºC |
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| MSDS | ChineseUSA | Flash Point | 321ºC |
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Names
| Name | sodium cholate |
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| Synonym | More Synonyms |
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sodium cholate BiologicalActivity
| Description | Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| In Vitro | Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. |
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| Cell Assay | HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section[1]. |
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| References | [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. |
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Chemical & Physical Properties
| Boiling Point | 583.9ºC at 760 mmHg |
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| Melting Point | 198ºC |
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| Molecular Formula | C24H40NaO5 |
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| Molecular Weight | 430.553 |
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| Flash Point | 321ºC |
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| Exact Mass | 430.269531 |
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| PSA | 100.82000 |
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| LogP | 2.11400 |
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| Index of Refraction | 35 ° (C=0.6, EtOH) |
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| InChIKey | NRHMKIHPTBHXPF-TUJRSCDTSA-M |
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| SMILES | CC(CCC(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.[Na+] |
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| Water Solubility | 150 g/L (20 ºC) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- FZ9600000
- CHEMICAL NAME :
- Cholic acid, sodium salt
- CAS REGISTRY NUMBER :
- 361-09-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C24-H39-O5.Na
- MOLECULAR WEIGHT :
- 430.62
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 DQ E1 FY1&2VO KQ OQ &-NA- &38/28
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine
- REFERENCE :
- ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 164 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Lungs, Thorax, or Respiration - other changes Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 90,18,1952
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS. Volume(issue)/page/year: 52,779,1926 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1798 No. of Facilities: 82 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 82 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1798 No. of Facilities: 585 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 6463 (estimated) No. of Female Employees: 4599 (estimated)
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | S24/25 |
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| RTECS | FZ9600000 |
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Synonyms
| colalin |
| cholic acid sodium |
| cholsaeure |
| sodium salt of cholic acid |
| Cholic acid,sodium salt |
| EINECS 206-643-5 |
| 7,12-Triol |
| Cholic acid |
| CHOLALIC ACID |
| SodiumCholate |
| CHOLIC ACID NA-SALT |
| 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt,Cholalic acid sodium salt |
| deoxycholic acid sodium salt |
| MFCD00064138 |
| SODIUMCHOLATE,REAGENT |
| SODIUM CHOLEATE |
| Sodium cholate |
| CHOLIC ACID SODIUM SALT |
