Introduction：Basic information about CAS 251945-92-3|SLV 320, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SLV 320 |
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| CAS Number | 251945-92-3 | Molecular Weight | 308.37800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H20N4O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol |
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| Synonym | More Synonyms |
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SLV 320 BiologicalActivity
| Description | Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor |
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| Target | Ki: 1 nM (adenosine A1 receptor)[1]. |
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| References | [1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32. |
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Chemical & Physical Properties
| Molecular Formula | C18H20N4O |
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| Molecular Weight | 308.37800 |
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| Exact Mass | 308.16400 |
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| PSA | 73.83000 |
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| LogP | 3.41330 |
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| InChIKey | RBZNJGHIKXAKQE-UHFFFAOYSA-N |
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| SMILES | OC1CCC(Nc2nc(-c3ccccc3)nc3[nH]ccc23)CC1 |
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Synonyms
| UNII-O1Q96UZ63W |
| SLV 320 |
| Derenofylline |
