Introduction：Basic information about CAS 312917-14-9|TCS JNK 5a, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TCS JNK 5a |
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| CAS Number | 312917-14-9 | Molecular Weight | 332.419 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 486.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H16N2OS | Melting Point | / |
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| MSDS | / | Flash Point | 248.2±28.7 °C |
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Names
| Name | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide |
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| Synonym | More Synonyms |
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TCS JNK 5a BiologicalActivity
| Description | TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>JNKResearch Areas >>Cancer |
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| Target | JNK3:6.7 (pIC50) JNK2:6.5 (pIC50) |
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| In Vitro | TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1]. |
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| References | [1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 486.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H16N2OS |
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| Molecular Weight | 332.419 |
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| Flash Point | 248.2±28.7 °C |
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| Exact Mass | 332.098328 |
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| PSA | 81.13000 |
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| LogP | 5.46 |
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| Appearance of Characters | light yellow solid |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.699 |
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| InChIKey | WQGDQGAFSDMBLA-UHFFFAOYSA-N |
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| SMILES | N#Cc1c(NC(=O)c2cccc3ccccc23)sc2c1CCCC2 |
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| Storage condition | Store at RT |
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Safety Information
Synonyms
| F0016-0404 |
| 1-Naphthalenecarboxamide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- |
| N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide |
| JNK Inhibitor IX |
| N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthamide |
| TCS JNK 5a |
| SC-20267 |
| N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide |
