Introduction：Basic information about CAS 33507-63-0|Substance P acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Substance P acetate salt |
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| CAS Number | 33507-63-0 | Molecular Weight | 1347.630 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C63H98N18O13S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Substance P |
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| Synonym | More Synonyms |
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Substance P acetate salt BiologicalActivity
| Description | Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Neurokinin ReceptorSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseNatural Products >>OthersPeptides |
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| Target | Human Endogenous Metabolite |
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| In Vitro | The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1]. |
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| References | [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C63H98N18O13S |
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| Molecular Weight | 1347.630 |
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| Exact Mass | 1346.728149 |
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| PSA | 544.43000 |
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| LogP | -0.85 |
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| Index of Refraction | 1.663 |
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| InChIKey | ADNPLDHMAVUMIW-CUZNLEPHSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(N)=O |
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| Storage condition | −20°C |
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| Water Solubility | H2O: 1 mg/mL | Soluble in water, DMSO, and Acetic Acid. |
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Safety Information
Synonyms
| UNII:675VGV5J1D |
| R-Phg-S-Leu |
| N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide |
| Aminophenylacetylleucine |
| L-Methioninamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |
| D-phenylglycyl-L-leucine |
| H-RPKPQQFFGLM-NH2 |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| neuropeptide substance P |
| RPKPQQFFGLM-NH2 |
| RPKPQQFFGLM |
| EINECS 251-545-8 |
