Introduction：Basic information about CAS 61596-47-2|Prolylleucine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Prolylleucine |
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| CAS Number | 61596-47-2 | Molecular Weight | 362.42000 |
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| Density | 1.224g/cm3 | Boiling Point | 593.7ºC at 760 mmHg |
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| Molecular Formula | C19H26N2O5 | Melting Point | / |
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| MSDS | / | Flash Point | 312.9ºC |
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Names
| Name | 4-methyl-2-[(1-phenylmethoxycarbonylpyrrolidine-2-carbonyl)amino]pentanoic acid |
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| Synonym | More Synonyms |
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Prolylleucine BiologicalActivity
| Description | Prolylleucine is a dipeptide containing branched-chain amino acids. |
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| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Cardiovascular Disease |
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| In Vitro | The addition of specific dipeptide containing branched-chain amino acids, such as Prolylleucine, to the growth medium negatively affects cell envelope-associated proteinase (CEP) activity, whereas dipeptides without branched-chain amino acids had no effect on the enzyme's production. To determine if certain peptides are involved in the regulation of CEP biosynthesis, eight specific dipeptides, one tripeptide, and two peptide fractions (LMMP and HMMP) from Casitone are evaluated. The CEP activity levels of L. delbrueckii subsp. lactis CRL 581 grown in MDM supplemented with LMMP are similar to those obtained in cells grown in minimal defined medium (MDM) supplemented with Casitone (99-fold reduction). The addition of leucylglycylglycine (LGG), leucylleucine (LL), leucylproline (LP), or Prolylleucine (PL) (final concentration, 1 mM) to MDM leads to a 6.5-, 7-, 4-, or 3.5-fold reduction in CEP activity, respectively. An increase of up to 5 mM in the concentration of these dipeptides results in a further two- or threefold reduction of CEP activity compared to the activity obtained in the presence of 1 mM of the peptide mentioned above. LGG, LL, LP, and Prolylleucine contain leucine as a branched-chain amino acid (BCAA). In contrast, no effect on CEP activity is observed by the supplementation of MDM with 1 to 5 mM of GT, PA, TG, GM, GP (dipeptides without BCAA), or HMMP. No inhibitory effect on proteinase activity from the presence of high concentrations (10-fold increase) of each of the 20 amino acids in the growth medium is observed. However, a 50-fold increase in BCAA concentration in MDM leads to a repression of proteinase synthesis of 40%. L. delbrueckii subsp. lactis is auxotrophic for BCAA[1]. |
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| References | [1]. Hebert EM, et al. Characterization of the pattern of alphas1- and beta-casein breakdown and release of a bioactive peptide by a cell envelope proteinase from Lactobacillus delbrueckii subsp. lactis CRL 581. Appl Environ Microbiol. 2008 Jun;74(12):3682-9. |
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Chemical & Physical Properties
| Density | 1.224g/cm3 |
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| Boiling Point | 593.7ºC at 760 mmHg |
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| Molecular Formula | C19H26N2O5 |
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| Molecular Weight | 362.42000 |
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| Flash Point | 312.9ºC |
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| Exact Mass | 362.18400 |
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| PSA | 95.94000 |
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| LogP | 2.73190 |
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| Index of Refraction | 1.554 |
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| InChIKey | YCYXUKRYYSXSLJ-CVEARBPZSA-N |
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| SMILES | CC(C)CC(NC(=O)C1CCCN1C(=O)OCc1ccccc1)C(=O)O |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
