CAS 131-18-0|Di-n-Amyl phthalate

Introduction：Basic information about CAS 131-18-0|Di-n-Amyl phthalate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Di-n-Amyl phthalate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles21
8. Synonyms

Common Name	Di-n-Amyl phthalate
CAS Number	131-18-0	Molecular Weight	306.40
Density	1.0±0.1 g/cm3	Boiling Point	357.0±10.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₆O₄	Melting Point	-55ºC
MSDS	ChineseUSA	Flash Point	188.8±8.5 °C
Symbol	GHS08, GHS09	Signal Word	Danger

Names

Name	dipentyl phthalate
Synonym	More Synonyms

Di-n-Amyl phthalate BiologicalActivity

Description	Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].
Related Catalog	Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease
References	[1]. Haiqiong Chen,et al. Exposure to dipentyl phthalate in utero disrupts the adrenalcortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPKphosphorylation. Environ Toxicol. 2023 May;38(5):997-1010. [2]. Bethany R Hannas,et al. Dipentyl phthalate dosing during sexual differentiation disruptsfetal testis function and postnatal development of the male Sprague-Dawley ratwith greater relative potency than other phthalates. Toxicol Sci. 2011Mar;120(1):184-93.

Description

Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].

Related Catalog

Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease

References

[1]. Haiqiong Chen,et al. Exposure to dipentyl phthalate in utero disrupts the adrenalcortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPKphosphorylation. Environ Toxicol. 2023 May;38(5):997-1010.

[2]. Bethany R Hannas,et al. Dipentyl phthalate dosing during sexual differentiation disruptsfetal testis function and postnatal development of the male Sprague-Dawley ratwith greater relative potency than other phthalates. Toxicol Sci. 2011Mar;120(1):184-93.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	357.0±10.0 °C at 760 mmHg
Melting Point	-55ºC
Molecular Formula	C₁₈H₂₆O₄
Molecular Weight	306.40
Flash Point	188.8±8.5 °C
Exact Mass	306.183105
PSA	52.60000
LogP	5.89
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.496
InChIKey	IPKKHRVROFYTEK-UHFFFAOYSA-N
SMILES	CCCCCOC(=O)c1ccccc1C(=O)OCCCCC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI1930000

CHEMICAL NAME :: Phthalic acid, dipentyl ester

CAS REGISTRY NUMBER :: 131-18-0

BEILSTEIN REFERENCE NO. :: 1987323

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H26-O4

MOLECULAR WEIGHT :: 306.44

WISWESSER LINE NOTATION :: 5OVR BVO5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6600 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,120,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2206 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,265,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,528,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 316 gm/kg

SEX/DURATION :: male 15 week(s) pre-mating female 15 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,508,1989 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989

Safety Information

Symbol	GHS08, GHS09
Signal Word	Danger
Hazard Statements	H360-H400
Precautionary Statements	P201-P273-P308 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R60
Safety Phrases	S45;S53;S61
RIDADR	UN 3082 9/PG 3
WGK Germany	3
RTECS	TI1930000
Packaging Group	III
HS Code	2917349000

Customs

HS Code	2917349000
Summary	2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles21

Analysis of phthalates in milk and milk products by liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry.

J. Chromatogr. A. 1362 , 110-8, (2014)

A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, ef...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

Synonyms

phthalic acid dipentyl ester

MFCD01861607

1,2-Benzenedicarboxylic acid, dipentyl ester

EINECS 205-017-9

Di-n-pentyl-phthalate

dipentyl benzene-1,2-dicarboxylate

Phthalic acid diamyl ester

Phthalic acid, pentyl 2-pentyl ester

UNII-5DC92K224X

DIAMYLPHTHALATE

Dipentyl phthalate

Phthalic acid di-n-pentyl ester

1,2-Benzenedicarboxylic acid dipentyl ester

di-n-pentyl phthalate

1,2-Benzenedicarboxylic acid, 1,2-dipentyl ester

DiaMyl Phthalate

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