CAS 36001-88-4|Amiprofos methyl
Introduction：Basic information about CAS 36001-88-4|Amiprofos methyl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amiprofos methyl | ||
|---|---|---|---|
| CAS Number | 36001-88-4 | Molecular Weight | 304.30 |
| Density | 1.275g/cm3 | Boiling Point | 389.9ºC at 760mmHg |
| Molecular Formula | C11H17N2O4PS | Melting Point | -65ºC |
| MSDS | ChineseUSA | Flash Point | 189.6ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | amiprofos-methyl |
|---|---|
| Synonym | More Synonyms |
Amiprofos methyl BiologicalActivity
| Description | Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
| In Vitro | Amiprofos methyl (APM) inhibits competitively the binding of [14C]oryzalin to tubulin with a Ki=5 μM. Amiprofos methyl concentrations inhibiting tobacco cell growth were within the threshold range of Amiprofos methyl concentrations that depolymerized cellular microtubules, indicating that growth inhibition is caused by microtubules depolymerization[2]. |
| References | [1]. Morejohn LC, et al. Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl. Science. 1984;224(4651):874-876. [2]. Murthy JV, et al. Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl. Plant Physiol. 1994;105(1):309-320. |
Chemical & Physical Properties
| Density | 1.275g/cm3 |
|---|---|
| Boiling Point | 389.9ºC at 760mmHg |
| Melting Point | -65ºC |
| Molecular Formula | C11H17N2O4PS |
| Molecular Weight | 304.30 |
| Flash Point | 189.6ºC |
| Exact Mass | 304.06500 |
| PSA | 118.21000 |
| LogP | 4.71560 |
| Index of Refraction | 1.553 |
| InChIKey | VHEWQRWLIDWRMR-UHFFFAOYSA-N |
| SMILES | COP(=S)(NC(C)C)Oc1ccc(C)cc1[N+](=O)[O-] |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 309 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 2,212,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TB5100000 |
| HS Code | 2929909011 |
Customs
| HS Code | 2929909011 |
|---|---|
| Summary | 2929909011 o-methyl o-(4-methyl-2-nitrophenyl) isopropylphosphoramidothioate |
Articles24
More Articles| Blockage of mitosis in maize root tips using colchicine-alternatives. Protoplasma 241(1-4) , 99-104, (2010) Mitosis in plants can be blocked by colchicine which has the capacity to bind microtubule subunits. In maize (Zea mays L.) breeding, it is frequently being used for doubling chromosome numbers of hapl... | |
| In vivo dynamics and differential microtubule-binding activities of MAP65 proteins. Plant Physiol. 136(4) , 3956-67, (2004) Plant cells produce different microtubule arrays that are essential for cell division and morphogenesis without equivalent in other eukaryotes. Microtubule-associated proteins influence the behavior o... | |
| Microtubule distribution in gravitropic protonemata of the moss Ceratodon. Protoplasma 159 , 60-9, (1990) Tip cells of dark-grown protonemata of the moss Ceratodon purpureus are negatively gravitropic (grow upward). They possess a unique longitudinal zonation: (1) a tip group of amylochloroplasts in the a... |
Synonyms
| O-methyl O-(4-methyl-2-nitrophenyl) N-(1-methylethyl)phosphoramidothioate |
| Amiprofos methyl |
| (RS)-(O-methyl O-2-nitro-p-tolyl isopropylphosphoramidothioate) |
| (Ξ)-[O-methyl O-(4-methyl-2-nitrophenyl) propan-2-ylphosphoramidothioate] |
| O-Methyl O-(2-nitro-p-tolyl) N-isopropylphosphoramidothionate |
| N-[methoxy-(4-methyl-2-nitrophenoxy)phosphinothioyl]propan-2-amine |
| amiprophos-methyl |
