Introduction：Basic information about CAS 61219-76-9|DL-Mevalonolactone-d3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DL-Mevalonolactone-d3 |
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| CAS Number | 61219-76-9 | Molecular Weight | 133.16000 |
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| Density | / | Boiling Point | 150ºC5 mm Hg(lit.) |
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| Molecular Formula | C6H7D3O3 | Melting Point | 28ºC(lit.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | D,L-Mevalonic Acid Lactone-d3 |
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| Synonym | More Synonyms |
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DL-Mevalonolactone-d3 BiologicalActivity
| Description | DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
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| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [3]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep108:133-145. |
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Chemical & Physical Properties
| Boiling Point | 150ºC5 mm Hg(lit.) |
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| Melting Point | 28ºC(lit.) |
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| Molecular Formula | C6H7D3O3 |
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| Molecular Weight | 133.16000 |
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| Exact Mass | 133.08200 |
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| PSA | 46.53000 |
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| LogP | 0.07440 |
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| InChIKey | JYVXNLLUYHCIIH-FIBGUPNXSA-N |
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| SMILES | CC1(O)CCOC(=O)C1 |
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Synonyms
| 4-hydroxy-4-(trideuteriomethyl)oxan-2-one |
