CAS 61949-77-7|trans-permethrin
| Common Name | trans-permethrin | ||
|---|---|---|---|
| CAS Number | 61949-77-7 | Molecular Weight | 391.28800 |
| Density | 1.293g/cm3 | Boiling Point | 465.9ºC at 760 mmHg |
| Molecular Formula | C21H20Cl2O3 | Melting Point | / |
| MSDS | USA | Flash Point | -18ºC |
| Symbol | GHS02, GHS07, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | (3-phenoxyphenyl)methyl (1R,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate |
|---|---|
| Synonym | More Synonyms |
trans-permethrin BiologicalActivity
| Description | trans-Permethrin is a transconfiguration of Permethrin (HY-B0887). Permethrin is an insecticide and neurotoxin[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| References | [1]. Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416. [2]. Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006933. |
Chemical & Physical Properties
| Density | 1.293g/cm3 |
|---|---|
| Boiling Point | 465.9ºC at 760 mmHg |
| Molecular Formula | C21H20Cl2O3 |
| Molecular Weight | 391.28800 |
| Flash Point | -18ºC |
| Exact Mass | 390.07900 |
| PSA | 35.53000 |
| LogP | 6.11330 |
| Index of Refraction | 1.615 |
| Storage condition | APPROX 4°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,153,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >135 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,153,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,329,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,329,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,329,1991
Safety Information
| Symbol | GHS02, GHS07, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H304-H315-H336-H410 |
| Precautionary Statements | P210-P261-P273-P301 + P310-P331-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F,Xn,N |
| Risk Phrases | 11-38-50/53-65-67 |
| Safety Phrases | S60;S61;S62 |
| RIDADR | UN 1145 3/PG 2 |
Articles47
More Articles| Plant essential oils affect the toxicities of carbaryl and permethrin against Aedes aegypti (Diptera: Culicidae). J. Med. Entomol. 50(4) , 826-32, (2013) ABSTRACT Phytochemicals have been considered as alternatives for conventional pesticides because of their low mammalian toxicity and environmental safety. They usually display less potent insecticidal... | |
| Field-collected permethrin-resistant Aedes aegypti from central Thailand contain point mutations in the domain IIS6 of the sodium channel gene (KDR). Southeast Asian J. Trop. Med. Public Health 43(6) , 1380-6, (2012) One of the mechanisms responsible for pyrethroid resistance in mosquitoes is mutations in domain IIS6 of voltage-gated sodium channel gene (kdr). Aedes aegypti larvae were collected from the central p... | |
| Efficacy of three insecticides against Anopheles dirus and Anopheles minimus, the major malaria vectors, in Kanchanaburi Province, Thailand. Southeast Asian J. Trop. Med. Public Health 43(6) , 1339-45, (2012) We conducted this study to determine the insecticide susceptibility of two malaria vectors, Anopheles dirus and Anopheles minimus from Kanchanaburi Province, Thailand. The mosquitoes were collected an... |
Synonyms
| EINECS 263-347-9 |
| MFCD00145431 |
| trans-Permethrin solution |
