CAS 1613439-56-7|Propranolol D7 hydrochloride
Introduction：Basic information about CAS 1613439-56-7|Propranolol D7 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Propranolol D7 hydrochloride | ||
|---|---|---|---|
| CAS Number | 1613439-56-7 | Molecular Weight | 266.38700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C16H15D7ClNO2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Propranolol D7 |
|---|
Propranolol D7 hydrochloride BiologicalActivity
| Description | Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
| Target | IC50: 12 nM (βAR)[1] |
| References | [1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. |
Chemical & Physical Properties
| Molecular Formula | C16H15D7ClNO2 |
|---|---|
| Molecular Weight | 266.38700 |
| Exact Mass | 266.20100 |
| PSA | 41.49000 |
| LogP | 2.96840 |
| InChIKey | ZMRUPTIKESYGQW-ODLOEXKQSA-N |
| SMILES | CC(C)NCC(O)COc1cccc2ccccc12.Cl |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| RIDADR | NONH for all modes of transport |
