CAS 16034-77-8|iocetamic acid (200 mg)

[1]. Owen JP, et al. Comparative study of iocetamic acid and calcium ipodate in the visualisation of the gallbladder and common bile duct. Clin Radiol. 1978 Sep;29(5):535-40.  

[2]. Janbroers JM, et al. Toxicologic studies of iocetamic acid in rats and dogs. Toxicol Appl Pharmacol. 1969 Mar;14(2):242-8.  

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UE6050000

CHEMICAL NAME :

Propionic acid, 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methy l-

CAS REGISTRY NUMBER :

16034-77-8

LAST UPDATED :

199612

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C12-H13-I3-N2-O3

MOLECULAR WEIGHT :

613.97

WISWESSER LINE NOTATION :

ZR BI DI FI CNV1&1Y1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7100 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

700 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

410 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,997,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6131 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 260 (estimated) No. of Female Employees: 140 (estimated)