CAS 2508-72-7|Antazoline Hydrochloride
Introduction：Basic information about CAS 2508-72-7|Antazoline Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Antazoline Hydrochloride | ||
|---|---|---|---|
| CAS Number | 2508-72-7 | Molecular Weight | 301.814 |
| Density | / | Boiling Point | 475.5ºC at 760 mmHg |
| Molecular Formula | C17H20ClN3 | Melting Point | 238 °C |
| MSDS | ChineseUSA | Flash Point | 241.4ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride |
|---|---|
| Synonym | More Synonyms |
Antazoline Hydrochloride BiologicalActivity
| Description | Antazoline hydrochloride is a 1st generation antihistamine with also anticholinergic properties used to relieve nasal congestion and in eye drops. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological Disease |
Chemical & Physical Properties
| Boiling Point | 475.5ºC at 760 mmHg |
|---|---|
| Melting Point | 238 °C |
| Molecular Formula | C17H20ClN3 |
| Molecular Weight | 301.814 |
| Flash Point | 241.4ºC |
| Exact Mass | 301.134583 |
| PSA | 27.63000 |
| LogP | 3.26130 |
| Vapour Pressure | 3.31E-09mmHg at 25°C |
| InChIKey | SWKDMSRRIBZZAY-UHFFFAOYSA-N |
| SMILES | Cl.c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 |
| Storage condition | Store at RT |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - irritability Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 10,338,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 17100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R20/21/22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NJ2150000 |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Antazoline Hydrochloride |
| hydrochloride salt of antazoline |
| Antazoline HCl |
| UNII-FP8Q8F72JH |
| Fenazolina |
| Antistine hydrochloride |
| Histazine |
| 2-(N-Benzylanilinomethyl)-2-imidazoline Hydrochloride |
| N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline hydrochloride (1:1) |
| Antazolinium chloratum |
| N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline,hydrochloride |
| MFCD00058145 |
| 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, hydrochloride (1:1) |
| EINECS 219-719-8 |
| Phenazoline hydrochloride |
| N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-anilin,Hydrochlorid |
| Antazoline (hydrochloride) |
