Introduction：Basic information about CAS 92264-81-8|Hydroxybupropion, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxybupropion |
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| CAS Number | 92264-81-8 | Molecular Weight | 255.74100 |
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| Density | 1.15 g/cm3 | Boiling Point | 393.9ºC at 760 mmHg |
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| Molecular Formula | C13H18ClNO2 | Melting Point | 121-123ºC |
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| MSDS | / | Flash Point | 192ºC |
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| Symbol |
GHS02, GHS07 | Signal Word | Danger |
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Names
| Name | Hydroxybupropione |
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| Synonym | More Synonyms |
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Hydroxybupropion BiologicalActivity
| Description | Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] . |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease |
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| Target | IC50: 1.7 μM (Norepinephrine uptake)[1] nACh receptor[1] |
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| References | [1]. Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82. |
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Chemical & Physical Properties
| Density | 1.15 g/cm3 |
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| Boiling Point | 393.9ºC at 760 mmHg |
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| Melting Point | 121-123ºC |
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| Molecular Formula | C13H18ClNO2 |
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| Molecular Weight | 255.74100 |
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| Flash Point | 192ºC |
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| Exact Mass | 255.10300 |
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| PSA | 49.33000 |
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| LogP | 2.66260 |
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| InChIKey | AKOAEVOSDHIVFX-UHFFFAOYSA-N |
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| SMILES | CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1 |
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| Storage condition | ?20°C |
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Safety Information
| Symbol |
GHS02, GHS07 |
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| Signal Word | Danger |
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| Hazard Statements | H225-H302 + H312 + H332-H319 |
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| Precautionary Statements | P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235 |
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| Hazard Codes | F,Xn |
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| Risk Phrases | 11-20/21/22-36 |
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| Safety Phrases | 16-36/37 |
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| RIDADR | UN 1648 3 / PGII |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
