CAS 4433-40-3|5-Hydroxymethyluracil
| Common Name | 5-Hydroxymethyluracil | ||
|---|---|---|---|
| CAS Number | 4433-40-3 | Molecular Weight | 142.113 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 530.4ºC at 760mmHg |
| Molecular Formula | C5H6N2O3 | Melting Point | >300 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 274.6ºC |
Names
| Name | 5-hydroxymethyluracil |
|---|---|
| Synonym | More Synonyms |
5-Hydroxymethyluracil BiologicalActivity
| Description | 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91. [2]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 530.4ºC at 760mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C5H6N2O3 |
| Molecular Weight | 142.113 |
| Flash Point | 274.6ºC |
| Exact Mass | 142.037842 |
| PSA | 86.47000 |
| LogP | -0.50 |
| Index of Refraction | 1.528 |
| InChIKey | JDBGXEHEIRGOBU-UHFFFAOYSA-N |
| SMILES | O=c1[nH]cc(CO)c(=O)[nH]1 |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 400 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,5466,1988
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 400 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,5466,1988
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YR0513000 |
| HS Code | 2933599090 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles29
More Articles| Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct. Toxicol. Lett. 155(3) , 403-10, (2005) 5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to rep... | |
| Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Nucleic Acids Res. 32(17) , 5291-302, (2004) Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-h... | |
| Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state. Radiat. Res. 161(4) , 442-50, (2004) HPLC analyses of condensed thymine irradiated with monochromatic synchrotron ultrasoft X rays in the energy region around nitrogen and oxygen K-shell edges were performed. Cobalt-60 gamma rays were us... |
Synonyms
| 5-(hydroxymethyl)-1H-pyrimidine-2,4-dione |
| EINECS 224-636-5 |
| 2,4-Pyrimidinediol, 5-(hydroxymethyl)- |
| 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione |
| 5-hydroxymethyluracil |
| MFCD00056024 |
| 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- |
| 5-(hydroxymethyl)-1,3-dihydropyrimidine-2,4-dione |
| 5-(Hydroxymethyl)uracil |
| 5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione |
