Introduction：Basic information about CAS 136647-02-4|UK-78282 Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | UK-78282 Hydrochloride |
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| CAS Number | 136647-02-4 | Molecular Weight | 466.05 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C29H36ClNO2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07, GHS09 | Signal Word | Warning |
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Names
| Name | 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine,hydrochloride |
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| Synonym | More Synonyms |
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UK-78282 Hydrochloride BiologicalActivity
| Description | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | IC50: 200 nM (Kv1.3)[1] |
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| References | [1]. D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16 |
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Chemical & Physical Properties
| Molecular Formula | C29H36ClNO2 |
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| Molecular Weight | 466.05 |
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| Exact Mass | 465.24300 |
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| PSA | 21.70000 |
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| LogP | 6.88590 |
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| InChIKey | ZZSQARULZYQMIG-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1.Cl |
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| Storage condition | -20°C |
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Safety Information
| Symbol |
GHS07, GHS09 |
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| Signal Word | Warning |
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| Hazard Statements | H319-H400 |
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| Precautionary Statements | P273-P305 + P351 + P338 |
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| RIDADR | UN 3077 9 / PGIII |
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| HS Code | 2933399090 |
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Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride |
| 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride |
