Introduction：Basic information about CAS 319-78-8|D-Isoleucine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
D-Isoleucine ((R)-Isoleucine), an isoleucine stereoisomer, is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine[1].
Related Catalog
Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References
[1]. Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33(8):3533-44.
Chemical & Physical Properties
Density
1.0±0.1 g/cm3
Boiling Point
225.8±23.0 °C at 760 mmHg
Melting Point
272-274ºC
Molecular Formula
C6H13NO2
Molecular Weight
131.173
Flash Point
90.3±22.6 °C
Exact Mass
131.094635
PSA
63.32000
LogP
0.73
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.463
InChIKey
AGPKZVBTJJNPAG-RFZPGFLSSA-N
SMILES
CCC(C)C(N)C(=O)O
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
NR4700000
CHEMICAL NAME :
Isoleucine, D-
CAS REGISTRY NUMBER :
319-78-8
BEILSTEIN REFERENCE NO. :
1721793
LAST UPDATED :
199803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZY2&1 -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6822 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956
Safety Information
Hazard Codes
Xn
Risk Phrases
R40
Safety Phrases
S24/25
RIDADR
NONH for all modes of transport
WGK Germany
3
RTECS
NR4700000
HS Code
2922499990
Customs
HS Code
2922499990
Summary
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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