Introduction：Basic information about CAS 66280-25-9|Gomisin J, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gomisin J |
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| CAS Number | 66280-25-9 | Molecular Weight | 388.454 |
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| Density | 1.161 | Boiling Point | 587.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H28O6 | Melting Point | 148-149 ºC |
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| MSDS | / | Flash Point | 309.1±30.1 °C |
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Names
| Name | Gomisin J |
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| Synonym | More Synonyms |
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Gomisin J BiologicalActivity
| Description | Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Epigenetics >>AMPKResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease |
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| Target | AMPK Ca2+ |
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| References | [1]. Ye BH, et al. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res. 2015 Mar;38(3):169-77. [2]. Kim M, et al. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. J Agric Food Chem. 2015 Nov 11;63(44):9729-39. |
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Chemical & Physical Properties
| Density | 1.161 |
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| Boiling Point | 587.5±50.0 °C at 760 mmHg |
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| Melting Point | 148-149 ºC |
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| Molecular Formula | C22H28O6 |
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| Molecular Weight | 388.454 |
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| Flash Point | 309.1±30.1 °C |
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| Exact Mass | 388.188599 |
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| PSA | 77.38000 |
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| LogP | 4.80 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.556 |
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| InChIKey | PICOUNAPKDEPCA-TXEJJXNPSA-N |
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| SMILES | COc1c(O)cc2c(c1OC)-c1c(cc(O)c(OC)c1OC)CC(C)C(C)C2 |
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Safety Information
Synonyms
| Dibenzo[a,c]cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-, (6R,7S)- |
| (-)-gomisin J |
| (6R,7S)-1,2,11,12-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene-3,10-diol |
| UNII:X13A57600T |
| 6(S),7(R)-Dibenzo(a,c)cyclooctene-3,10-diol,5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl |
| Dibenzo(a,c)cyclooctene-3,10-diol,5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-,stereoisomer |
