CAS 1374598-80-7|Fasiglifam(TAK-875)
Introduction：Basic information about CAS 1374598-80-7|Fasiglifam(TAK-875), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fasiglifam(TAK-875) | ||
|---|---|---|---|
| CAS Number | 1374598-80-7 | Molecular Weight | 533.63 |
| Density | / | Boiling Point | / |
| Molecular Formula | C29H33O7.5S | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid,hydrate |
|---|---|
| Synonym | More Synonyms |
Fasiglifam(TAK-875) BiologicalActivity
| Description | Fasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GPR40Research Areas >>Metabolic Disease |
| Target | EC50: 72 nM (GPR40)[1] |
| References | [1]. Tsujihata Y,et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.J Pharmacol Exp [2]. Yoshiyuki Tsujihata, et al. TAK-875, an Orally Available GPR40/FFA1 Agonist Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats. JPET July 13, 2011 [3]. Nagatake T, et al. 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2017 Dec 26. pii: S0091-6749(17)32949-4. |
Chemical & Physical Properties
| Molecular Formula | C29H33O7.5S |
|---|---|
| Molecular Weight | 533.63 |
| Exact Mass | 1066.38000 |
| PSA | 224.25000 |
| LogP | 12.72450 |
| InChIKey | OJXYMYYDAVXPIK-IWKNALKQSA-N |
| SMILES | Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1.O |
| Storage condition | -20℃ |
Synonyms
| (3S)-6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy) biphenyl-3-yl)methoxy)-2,3-dihydro-l-benzofuran-3-yl)acetic acid hemihydrate |
| (3S)-6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy) biphenyl-3-yl)methoxy)-2,3-dihydro-l-benzofuran-3-yl)acetic acid hydrate |
| Fasiglifam hemihydrate |
| UNII-8LDT91CH8A |
| 3-Benzofuranacetic acid,6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)(1,1'-biphenyl)-3-yl)methoxy)-2,3-dihydro-,hydrate (2:1),(3S) |
| TAK875 |
