Introduction：Basic information about CAS 448954-98-1|NH2-O-C5-COOH hydrobromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NH2-O-C5-COOH hydrobromide |
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| CAS Number | 448954-98-1 | Molecular Weight | 228.08400 |
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| Density | / | Boiling Point | 349.5ºC at 760 mmHg |
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| Molecular Formula | C6H14BrNO3 | Melting Point | / |
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| MSDS | / | Flash Point | 165.2ºC |
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Names
| Name | 6-aminooxyhexanoic acid,hydrobromide |
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| Synonym | More Synonyms |
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NH2-O-C5-COOH hydrobromide BiologicalActivity
| Description | NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Boiling Point | 349.5ºC at 760 mmHg |
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| Molecular Formula | C6H14BrNO3 |
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| Molecular Weight | 228.08400 |
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| Flash Point | 165.2ºC |
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| Exact Mass | 227.01600 |
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| PSA | 72.55000 |
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| LogP | 2.18010 |
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| InChIKey | BGUDSFOAMPGEOX-UHFFFAOYSA-N |
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| SMILES | Br.NOCCCCCC(=O)O |
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Synonyms
| 6-Aminooxy-hexanoic acid hydrobromide |
| 6-Aminooxy-hexanoic acid |
| Hexanoicacid,6-(aminooxy)-,hydrobromide (1:1) |
