CAS 3681-93-4|vitexin

Introduction：Basic information about CAS 3681-93-4|vitexin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. vitexin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles7
7. Synonyms

Common Name	vitexin
CAS Number	3681-93-4	Molecular Weight	432.378
Density	1.7±0.1 g/cm3	Boiling Point	767.7±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₀O₁₀	Melting Point	256-257ºC
MSDS	ChineseUSA	Flash Point	273.1±26.4 °C

Names

Name	vitexin
Synonym	More Synonyms

vitexin BiologicalActivity

Description	Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects[1][2].
Related Catalog	Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease
In Vivo	Vitexin exerts neuroprotective effect against pentylenetetrazole-induced seizures, scopolamine-induced memory impairment, and glutamate-induced neuronal excitotoxicity[1].
References	[1]. He M, et al. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016 Dec;115:74-85. [2]. Lima LKF, et al. A Brief Review on the Neuroprotective Mechanisms of Vitexin. Biomed Res Int. 2018 Dec 5;2018:4785089.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	767.7±60.0 °C at 760 mmHg
Melting Point	256-257ºC
Molecular Formula	C₂₁H₂₀O₁₀
Molecular Weight	432.378
Flash Point	273.1±26.4 °C
Exact Mass	432.105652
PSA	181.05000
LogP	1.28
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.743
InChIKey	SGEWCQFRYRRZDC-VPRICQMDSA-N
SMILES	O=c1cc(-c2ccc(O)cc2)oc2c(C3OC(CO)C(O)C(O)C3O)c(O)cc(O)c12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2984000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-beta-D-glucopyranosyl-2-(4-hydroxyphe nyl)-

CAS REGISTRY NUMBER :: 3681-93-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H20-O10

MOLECULAR WEIGHT :: 432.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD25 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 200 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ2984000
HS Code	29389090

Articles7

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant Desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy.

J. Pharm. Biomed. Anal. 102 , 54-63, (2014)

The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrop...

In vitro and in silico studies to explore structural features of flavonoids for aldehyde oxidase inhibition.

Arch. Pharm. (Weinheim) 347(10) , 738-47, (2014)

Aldehyde oxidase (AO), an important enzyme in the biotransformation of drugs and xenobiotics, is inhibited by flavonoids. This enzyme can metabolize both aldehydes and N-heterocycles. In this work, a ...

Synonyms

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-β-D-glucopyranosyl-2-(4-hydroxyphenyl)-

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-β-D- glucopyranosyl-2-(4-hydroxyphenyl)-

8-Glucosylapigenin

vitexin

Apigenin8-C-glucoside

8-b-D-Glucopyranosyl-apigenin

ORIENTOSIDE

Apigenin 8-C-β-D-glucopyranoside

Vitxein

4H-1-Benzopyran-4-one, 8-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-

5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-one

D-Glucitol, 1,5-anhydro-1-C-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-, (1S)-

8-D-Glucosyl-4',5,7-trihydroxyflavone

8-β-D-Glucopyranosyl-apigenin

(1S)-1,5-Anhydro-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol

8-β-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Apigenin 8-C-glucoside

Apigenin-8-C-glucoside

4',5,7-trihydroxyflavone-8-C-glucoside

5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-on

5,7-Dihydroxy-2-(4-hydroxyphényl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]-4H-chromén-4-one

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