CAS 132834-56-1|Org 12962
Introduction：Basic information about CAS 132834-56-1|Org 12962, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Org 12962 | ||
|---|---|---|---|
| CAS Number | 132834-56-1 | Molecular Weight | 265.66300 |
| Density | 1.454g/cm3 | Boiling Point | 286.004ºC at 760 mmHg |
| Molecular Formula | C10H11ClF3N3 | Melting Point | / |
| MSDS | / | Flash Point | 126.771ºC |
Names
| Name | 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine |
|---|---|
| Synonym | More Synonyms |
Org 12962 BiologicalActivity
| Description | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | 5-HT2C Receptor:7.01 (pEC50) 5-HT2A Receptor:6.38 (pEC50) 5-HT2B Receptor:6.28 (pEC50) |
| In Vivo | Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1]. Animal Model: Male Wistar rats[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3.2 mg/kg Administration: Intraperitoneal injection; 0.3-3.2 mg/kg Result: Induced a dose-related antipanic-like effect. |
| References | [1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. |
Chemical & Physical Properties
| Density | 1.454g/cm3 |
|---|---|
| Boiling Point | 286.004ºC at 760 mmHg |
| Molecular Formula | C10H11ClF3N3 |
| Molecular Weight | 265.66300 |
| Flash Point | 126.771ºC |
| Exact Mass | 265.05900 |
| PSA | 28.16000 |
| LogP | 2.55720 |
| Vapour Pressure | 0.001mmHg at 25°C |
| Index of Refraction | 1.541 |
| InChIKey | QZYYPQAYSFBKPW-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccc(N2CCNCC2)nc1Cl |
Safety Information
| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| MFCD00892750 |
