Introduction：Basic information about CAS 63119-27-7|Anitrazafen, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Anitrazafen |
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| CAS Number | 63119-27-7 | Molecular Weight | 307.34600 |
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| Density | 1.164g/cm3 | Boiling Point | 482.8ºC at 760 mmHg |
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| Molecular Formula | C18H17N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | 172.1ºC |
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Names
| Name | 5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine |
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| Synonym | More Synonyms |
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Anitrazafen BiologicalActivity
| Description | Anitrazafen is a topically effective antiinflammatory agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vivo | Anitrazafen is a topically effective antiinflammatory agent. The disposition of 14C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3-14C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total 14C after subcutaneous administration of [3-14C]Anitrazafen in corn oil solution are about one half those found after oral administration[1]. |
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| Animal Admin | Male albino rats (200 to 250 g) are fasted for 24 h before experiment. [3-14C]Anitrazafen (25 mg/kg) is administered orally to twelve rats. At specific times after dosing, three animals are killed by decapitation and samples of blood and appropriate tissues are removed. Duplicate weighed samples of blood and each tissue are removed for 14C assay[1]. |
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| References | [1]. Sullivan HR, et al. Absorption and metabolism of anitrazafen, a topically effective anti-inflammatory agent, in the rat. Xenobiotica. 1981 Jan;11(1):9-22. |
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Chemical & Physical Properties
| Density | 1.164g/cm3 |
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| Boiling Point | 482.8ºC at 760 mmHg |
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| Molecular Formula | C18H17N3O2 |
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| Molecular Weight | 307.34600 |
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| Flash Point | 172.1ºC |
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| Exact Mass | 307.13200 |
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| PSA | 57.13000 |
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| LogP | 3.53120 |
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| Index of Refraction | 1.58 |
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| InChIKey | HDNJXZZJFPCFHG-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2nnc(C)nc2-c2ccc(OC)cc2)cc1 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933699090 |
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| Summary | 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
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Synonyms
| ANITRAZAFEN |
| Anitrazafene |
| Anitrazafenum |
| Anitrazafeno |
