CAS 3102-56-5|D,L-erythro-Dihydrosphingosine
| Common Name | D,L-erythro-Dihydrosphingosine | ||
|---|---|---|---|
| CAS Number | 3102-56-5 | Molecular Weight | 301.50800 |
| Density | 0.927g/cm3 | Boiling Point | 446.2ºC at 760 mmHg |
| Molecular Formula | C18H39NO2 | Melting Point | 70-72ºC |
| MSDS | ChineseUSA | Flash Point | 223.7ºC |
Names
| Name | DL-erythro-Dihydrosphingosine |
|---|---|
| Synonym | More Synonyms |
D,L-erythro-Dihydrosphingosine BiologicalActivity
| Description | DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2)[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseSignaling Pathways >>TGF-beta/Smad >>PKC |
| References | [1]. R Chao, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267(33):23459-62. [2]. Hiroyuki Nakamura, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17. |
Chemical & Physical Properties
| Density | 0.927g/cm3 |
|---|---|
| Boiling Point | 446.2ºC at 760 mmHg |
| Melting Point | 70-72ºC |
| Molecular Formula | C18H39NO2 |
| Molecular Weight | 301.50800 |
| Flash Point | 223.7ºC |
| Exact Mass | 301.29800 |
| PSA | 66.48000 |
| LogP | 4.84850 |
| Appearance of Characters | white |
| Index of Refraction | 1.477 |
| InChIKey | OTKJDMGTUTTYMP-QZTJIDSGSA-N |
| SMILES | CCCCCCCCCCCCCCCC(O)C(N)CO |
| Storage condition | −20°C |
| Water Solubility | chloroform/methanol (9:1): 20 mg/mL, clear, colorless to faintly yellow |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922199090 |
Customs
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles29
More Articles| Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. Biochem. J. 461(2) , 213-22, (2014) Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as v... | |
| Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. Arch. Biochem. Biophys. 526(1) , 60-8, (2012) The role of sphingolipids in clathrin-mediated endocytosis is only poorly understood in mammalian cells. Thus the relationship between sphingolipid de novo synthesis and clathrin-mediated endocytosis ... | |
| Terpene alcohols inhibit de novo sphingolipid biosynthesis. Planta Med. 78(5) , 434-9, (2012) The terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK₁ cells (pig kidney epithe... |
Synonyms
| EINECS 212-116-0 |
| DL-erythro-1,3-Dihydroxy-2-aminooctadecane,DL-erythro-2-Amino-1,3-octadecanediol,DL-Sphinganine |
| DL-erythro-1,3-Dihydroxy-2-aminooctadecane DL-erythro-2-Amino-1,3-octadecanediol DL-Sphinganine |
| DL-ERYTHRO-DIHYDROSPHINGOSINE |
| MFCD00079141 |
