CAS 441785-25-7|Besifovir

Introduction：Basic information about CAS 441785-25-7|Besifovir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Besifovir BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Besifovir
CAS Number	441785-25-7	Molecular Weight	299.223
Density	1.9±0.1 g/cm3	Boiling Point	668.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₄N₅O₄P	Melting Point	/
MSDS	/	Flash Point	358.0±34.3 °C

Names

Name	[1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid
Synonym	More Synonyms

Besifovir BiologicalActivity

Description	Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV
References	[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. [2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

Description

Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV

References

[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64.

[2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

Chemical & Physical Properties

Density	1.9±0.1 g/cm3
Boiling Point	668.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₄N₅O₄P
Molecular Weight	299.223
Flash Point	358.0±34.3 °C
Exact Mass	299.078339
PSA	146.19000
LogP	-2.56
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.826
InChIKey	KDNSSKPZBDNJDF-UHFFFAOYSA-N
SMILES	Nc1ncc2ncn(CC3(OCP(=O)(O)O)CC3)c2n1

Safety Information

HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

UNII-4PLG22CQUU

[({1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acid

Besifovir

Phosphonic acid, [[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-

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