CAS 77327-45-8|(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt
| Common Name | (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 77327-45-8 | Molecular Weight | 1075.304 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1537.6±65.0 °C at 760 mmHg |
| Molecular Formula | C48H74N12O12S2 | Melting Point | / |
| MSDS | USA | Flash Point | 883.7±34.3 °C |
Names
| Name | [Pmp1,Tyr(OMe)2,Orn8] Vasotocin |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) is an oxytocin receptor antagonist. (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin can be used for the research of neurological disease[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Oxytocin ReceptorResearch Areas >>Neurological Disease |
| References | [1]. Mullis K, et al. Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Res. 2013 Jun 4;1513:85-91. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 1537.6±65.0 °C at 760 mmHg |
| Molecular Formula | C48H74N12O12S2 |
| Molecular Weight | 1075.304 |
| Flash Point | 883.7±34.3 °C |
| Exact Mass | 1074.499023 |
| PSA | 439.13000 |
| LogP | -2.55 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.625 |
| InChIKey | ZWVZXPFUQHTUKV-UHFFFAOYSA-N |
| SMILES | CCC(C)C1NC(=O)C(Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSCC(C(=O)N2CCCC2C(=O)NC(CCCN)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
Articles25
More Articles| Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats. Neuropeptides 27(4) , 245-50, (1994) In intact, non-ovariectomized female rats in spontaneous behavioral estrus, the i.c.v. injection of oxytocin significantly increased lordosis quotient and lordosis duration, starting from a dose of 1 ... | |
| Effect of oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin in the rat. J. Endocrinol. 152(2) , 257-64, (1997) The effect of three oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin was investigated in conscious male rats infused with hypotonic saline. Infusion of oxytocin at 100 pg... | |
| The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci. Lett. 265(3) , 171-4, (1999) Male rats show four to six penile erection episodes when put for 80 min in the presence of an inaccessible receptive female. These non-contact penile erections were reduced dose-dependently by d(CH2)5... |
Synonyms
| b-Mercapto-b,b-cyclopentaMethylene-propionyl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 |
| [D(CH2)51,TYR(ME)2,ORN8]-VASOTOCIN |
| (D(CH2)(5/1),TYR(ME)2,ORN8)-OXYTOCIN |
| PMP-TYR(ME)-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2 |
| 1-{[(10R,13S,16S,19S,22S)-13-(2-Amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-[(2S)-2-butanyl]-22-(4-methoxybenzyl)-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl}-L-prolyl-L-ornithylglycinamide |
| Glycinamide, 1-[[(10R,13S,16S,19S,22S)-13-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-22-[(4-methoxyphenyl)methyl]-19-[(1S)-1-methylpropyl]-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl]-L-prolyl-L-ornithyl- |
| (D(CH2)51,(METHYL)TYR2,ORN8)-OXYTOCIN |
| me)(2)-orn(8) |
