CAS 109333-26-8|(D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt

Introduction：Basic information about CAS 109333-26-8|(D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt
CAS Number	109333-26-8	Molecular Weight	1282.45
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₆₀H₈₇N₁₉O₁₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	[D-Arg0,Hyp3,D-Phe7]-Bradykinin
Synonym	More Synonyms

BiologicalActivity

Description	NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Bradykinin Receptor
References	[1]. Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72. [2]. Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9.

Description

NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2].

Related Catalog

Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Bradykinin Receptor

References

[1]. Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72.

[2]. Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₆₀H₈₇N₁₉O₁₃
Molecular Weight	1282.45
Exact Mass	1281.673096
PSA	533.80000
LogP	-2.56
Index of Refraction	1.691
InChIKey	RBIXVHPHNGXTCI-QJTYZATASA-N
SMILES	NC(N)=NCCCC(N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)O

Safety Information

WGK Germany	3

Synonyms

(D-ARG0,HYP3,D-PHE7)-BRADYKININ

D-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-D-Arg-OH

D-ARG-ARG-PRO-HYDROXY-PRO-GLY-PHE-SER-D-PHE-PHE-ARG

D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG

D-Phe7]-bradykinin

D-Arg-Arg-Pro-Hyp-Gly-Phe-Phe-Arg

(D-Arg0,Hyp3,D-Phe7)bradikinin

D-Arg[Hyp3,D-Phe7]-bradykinin

D-Arg-Arg-Pro-t4Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-

npc567

D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-L-Arg-OH

D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-L-arginine

H-D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG-OH

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