CAS 33889-69-9|Silicristin
| Common Name | Silicristin | ||
|---|---|---|---|
| CAS Number | 33889-69-9 | Molecular Weight | 482.436 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 782.0±60.0 °C at 760 mmHg |
| Molecular Formula | C25H22O10 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 270.5±26.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | silychristin |
|---|---|
| Synonym | More Synonyms |
Silicristin BiologicalActivity
| Description | Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Others |
| References | [1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092. [2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 782.0±60.0 °C at 760 mmHg |
| Molecular Formula | C25H22O10 |
| Molecular Weight | 482.436 |
| Flash Point | 270.5±26.4 °C |
| Exact Mass | 482.121307 |
| PSA | 166.14000 |
| LogP | 2.20 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.716 |
| InChIKey | BMLIIPOXVWESJG-LMBCONBSSA-N |
| SMILES | COc1cc(C2Oc3c(O)cc(C4Oc5cc(O)cc(O)c5C(=O)C4O)cc3C2CO)ccc1O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| Safety Phrases | 22-45 |
| RIDADR | NONH for all modes of transport |
Articles15
More Articles| Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol. Res. 25(2) , 147-54, (1992) The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro... | |
| Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. A. 1116(1-2) , 57-68, (2006) A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t... | |
| Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int. J. Cancer 123(1) , 41-50, (2008) Prostate cancer (PCa) is the leading cause of cancer-related deaths in men; urgent measures are warranted to lower this deadly malignancy. Silymarin is a known cancer chemopreventive agent, but the re... |
Synonyms
| Silicristin |
| EINECS 251-720-9 |
| Silicristinum |
| (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one |
| Silicristinum [INN-Latin] |
| Silicristina |
| (2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one |
| Silicristina [INN-Spanish] |
| 4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- |
| Silychristin |
| Silymarin II |
| Silicristine [INN-French] |
| (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-2,3-dihydrobenzofuran-5-yl]chroman-4-one |
| Silicristine |
