CAS 65995-63-3|Punicalagin
| Common Name | Punicalagin | ||
|---|---|---|---|
| CAS Number | 65995-63-3 | Molecular Weight | 1084.718 |
| Density | 2.1±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C48H28O30 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Punicalagin |
|---|---|
| Synonym | More Synonyms |
Punicalagin BiologicalActivity
| Description | Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>HBVResearch Areas >>Metabolic Disease |
| In Vitro | Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells[1]. |
| In Vivo | Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats[2]. |
| References | [1]. Seeram NP, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagicacid and a total pomegranate tannin extract are enhanced in combination with otherpolyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7. [2]. Lin CC, et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6. [3]. Liu C, et al. Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Res. 2016 Oct;134:97-107. |
Chemical & Physical Properties
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Molecular Formula | C48H28O30 |
| Molecular Weight | 1084.718 |
| Exact Mass | 1084.066528 |
| PSA | 518.76000 |
| LogP | 2.36 |
| Appearance of Characters | faint yellow to dark yellow |
| Index of Refraction | 1.893 |
| InChIKey | ZJVUMAFASBFUBG-OGJBWQGYSA-N |
| SMILES | O=C1OC2C(O)OC3COC(=O)c4cc(O)c(O)c(O)c4-c4c(O)c(O)c5oc(=O)c6c(c(O)c(O)c7oc(=O)c4c5c76)-c4c(cc(O)c(O)c4O)C(=O)OC3C2OC(=O)c2cc(O)c(O)c(O)c2-c2c1cc(O)c(O)c2O |
| Storage condition | 2-8°C |
| Water Solubility | methanol: soluble5mg/mL, clear |
Safety Information
| Hazard Codes | Xi |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
Articles30
More Articles| Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J. Agric. Food Chem. 57(22) , 10636-44, (2009) The cytochrome P450 enzyme, CYP1B1, is an established target in prostate cancer chemoprevention. Compounds inhibiting CYP1B1 activity are contemplated to exert beneficial effects at three stages of pr... | |
| Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae). Nat. Prod. Res. 24(20) , 1915-26, (2010) The aqueous extract of galls from Terminalia chebula Retz. (Combretaceae) was fractionated on Diaion and refractionated on octadecyl silica column. Six phenolic compounds were isolated and identified ... | |
| Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum). J. Cosmet. Sci. 64(6) , 445-53, (2013) Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limi... |
Synonyms
| pulchinenoside b4(rg) |
| 1,2,3,11,12,13-Hexahydroxy-5,10-dioxo-8-[3,4,5,11,17,18,19,22,23,34,35-undecahydroxy-8,14,26,31-tetraoxo-9,13,25,32-tetraoxaheptacyclo[25.8.0.0.0.0.0.0]pentatriaconta- 1(35),2,4,6,15,17,19,21,23,27,29,33-dodecaen-10-yl]-5,7,8,10-tetrahydrodibenzo[f,h][1,4]dioxecine-7-carbaldehyde |
