CAS 31271-07-5|gamma-Mangostin

Introduction：Basic information about CAS 31271-07-5|gamma-Mangostin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. gamma-Mangostin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	gamma-Mangostin
CAS Number	31271-07-5	Molecular Weight	396.433
Density	1.3±0.1 g/cm3	Boiling Point	648.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₄O₆	Melting Point	/
MSDS	/	Flash Point	226.4±25.0 °C

Names

Name	γ-mangostin
Synonym	More Synonyms

gamma-Mangostin BiologicalActivity

Description	Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1].
Target	5-hydroxytryptamine 2A (5-HT2A) receptors[1]
References	[1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31. [2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.

Description

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1].

Target

5-hydroxytryptamine 2A (5-HT2A) receptors[1]

References

[1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.

[2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	648.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₄O₆
Molecular Weight	396.433
Flash Point	226.4±25.0 °C
Exact Mass	396.157288
PSA	111.13000
LogP	5.14
Appearance of Characters	off-white to yellow
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.656
InChIKey	VEZXFTKZUMARDU-UHFFFAOYSA-N
SMILES	CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O
Storage condition	2-8°C
Water Solubility	methanol: soluble1mg/mL, colorless to yellow

Safety Information

Hazard Codes	Xn
Risk Phrases	22
RTECS	ZD6122330
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-

9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-

2,8-Bis(3-methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9H-xanthen-9-one

gamma-mangostin

r-mangostin

1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one

normangostin

Mangostin, γ-

Recommended......