Introduction：Basic information about CAS 166108-71-0|Fmoc-8-amino-3,6-dioxaoctanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fmoc-8-amino-3,6-dioxaoctanoic acid |
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| CAS Number | 166108-71-0 | Molecular Weight | 385.410 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 631.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C21H23NO6 | Melting Point | 90-92℃ |
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| MSDS | / | Flash Point | 335.6±28.7 °C |
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Names
| Name | [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid |
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| Synonym | More Synonyms |
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Fmoc-8-amino-3,6-dioxaoctanoic acid BiologicalActivity
| Description | Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
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| References | [1]. Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 631.4±45.0 °C at 760 mmHg |
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| Melting Point | 90-92℃ |
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| Molecular Formula | C21H23NO6 |
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| Molecular Weight | 385.410 |
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| Flash Point | 335.6±28.7 °C |
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| Exact Mass | 385.152527 |
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| PSA | 94.09000 |
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| LogP | 2.63 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.580 |
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| InChIKey | XQPYRJIMPDBGRW-UHFFFAOYSA-N |
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| SMILES | O=C(O)COCCOCCNC(=O)OCC1c2ccccc2-c2ccccc21 |
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| Storage condition | -15°C |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2,7,10-Trioxa-4-azadodecan-12-oic acid, 1-(9H-fluoren-9-yl)-3-oxo- |
| [2-[2-(Fmoc-Amino)ethoxy]ethoxy]acetic acid |
| [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid |
| 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid |
| {2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-acetic acid |
| Fmoc-NH-PEG2-CH2COOH |
| MFCD01321015 |
| 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid |
| [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid |
| 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid |
| 8-[(9H-Fluoren-9-ylMethoxy)carbonylaMino]-3,6-dioxa-n-octanoic Acid |
| Fmoc-mini-PEG |
| Fmoc-AEEA |
