Introduction：Basic information about CAS 82005-12-7|10Z-Hymenialdisine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 10Z-Hymenialdisine |
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| CAS Number | 82005-12-7 | Molecular Weight | 324.13300 |
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| Density | 2.2 g/cm3 | Boiling Point | / |
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| Molecular Formula | C11H10BrN5O2 | Melting Point | 160-164ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 10z-hymenialdisine |
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| Synonym | More Synonyms |
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10Z-Hymenialdisine BiologicalActivity
| Description | 10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PDGFRSignaling Pathways >>PI3K/Akt/mTOR >>AMPKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
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| In Vitro | 10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1]. |
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| References | [1]. Ashraf N E Hamed, et al. Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri. Z Naturforsch C J Biosci. 2018 Apr 25;73(5-6):199-210. |
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Chemical & Physical Properties
| Density | 2.2 g/cm3 |
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| Melting Point | 160-164ºC |
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| Molecular Formula | C11H10BrN5O2 |
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| Molecular Weight | 324.13300 |
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| Exact Mass | 323.00200 |
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| PSA | 112.37000 |
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| LogP | 0.85980 |
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| Index of Refraction | 1.911 |
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| InChIKey | ATBAETXFFCOZOY-UHFFFAOYSA-N |
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| SMILES | NC1=NC(=C2CCNC(=O)c3[nH]c(Br)cc32)C(=O)N1 |
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Synonyms
