CAS 71636-61-8|(+/-)-4-HYDROXYDEBRISOQUIN
| Common Name | (+/-)-4-HYDROXYDEBRISOQUIN | ||
|---|---|---|---|
| CAS Number | 71636-61-8 | Molecular Weight | 370.66900 |
| Density | 1.299 g/cm3 | Boiling Point | 467.3ºC at 760 mmHg |
| Molecular Formula | C16H17BrClNO2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 236.4ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol |
|---|---|
| Synonym | More Synonyms |
(+/-)-4-HYDROXYDEBRISOQUIN BiologicalActivity
| Description | SKF 81297 is a potent and selective dopamine D1 receptor agonist[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
| Target | D1 Receptor |
| References | [1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844. |
Chemical & Physical Properties
| Density | 1.299 g/cm3 |
|---|---|
| Boiling Point | 467.3ºC at 760 mmHg |
| Molecular Formula | C16H17BrClNO2 |
| Molecular Weight | 370.66900 |
| Flash Point | 236.4ºC |
| Exact Mass | 369.01300 |
| PSA | 52.49000 |
| LogP | 4.31570 |
| InChIKey | GHWJEDJMOVUXEC-UHFFFAOYSA-N |
| SMILES | Oc1cc2c(c(Cl)c1O)CCNCC2c1ccccc1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 22-26-36 |
| RIDADR | NONH for all modes of transport |
Articles29
More Articles| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened... | |
| Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine. PLoS ONE 8(3) , e57054, (2013) D1 and D2 receptor expressing striatal medium spiny neurons (MSNs) are ascribed to striatonigral ("direct") and striatopallidal ("indirect") pathways, respectively, that are believed to function antag... | |
| Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats. Eur. J. Neurosci. 32(4) , 579-90, (2010) Whole-cell patch-clamp recordings of non-N-methyl-d-aspartate glutamatergic excitatory postsynaptic currents (EPSCs) were carried out from cholinergic neurons in slices of basal forebrain (BF) of deve... |
Synonyms
| 6-Chlor-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin |
| 8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| C16H16ClNO2 |
| 1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl |
| 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol |
| 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol |
| MFCD00153782 |
