Introduction：Basic information about CAS 587-61-1|Propyliodone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Propyliodone |
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| CAS Number | 587-61-1 | Molecular Weight | 447.00800 |
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| Density | 2.14g/cm3 | Boiling Point | 392.6ºC at 760mmHg |
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| Molecular Formula | C10H11I2NO3 | Melting Point | 186°C |
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| MSDS | / | Flash Point | 191.2ºC |
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Names
| Name | propyl 2-(3,5-diiodo-4-oxopyridin-1-yl)acetate |
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| Synonym | More Synonyms |
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Propyliodone BiologicalActivity
| Description | Propyliodone is a compound used as a contrast medium in bronchography[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vivo | Propyliodone (crico-thyroid membrane injection; 1 mL, in diodone (50% w/v); once) induces lung irritation in vivo[1]. Animal Model: Rabbits with sodium pentobarbitone and chloralose injection[1] Dosage: 1 mL, in diodone (50% w/v) Administration: Crico-thyroid membrane injection; 1 mL, in diodone (50% w/v); once Result: Showed macroscopic signs of lung irritation at 16 hours, reached a maximum at three days and appeared normal after two weeks. Caused a few scatteredfoci of round cell infiltration in the interstitialtissue adjoining the small bronchi of the rabbits. |
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Chemical & Physical Properties
| Density | 2.14g/cm3 |
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| Boiling Point | 392.6ºC at 760mmHg |
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| Melting Point | 186°C |
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| Molecular Formula | C10H11I2NO3 |
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| Molecular Weight | 447.00800 |
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| Flash Point | 191.2ºC |
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| Exact Mass | 446.88300 |
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| PSA | 48.30000 |
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| LogP | 2.01070 |
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| Index of Refraction | 1.663 |
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| InChIKey | ROSXARVHJNYYDO-UHFFFAOYSA-N |
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| SMILES | CCCOC(=O)Cn1cc(I)c(=O)c(I)c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UR8925000
- CHEMICAL NAME :
- 1(4H)-Pyridineacetic acid, 3,5-diiodo-4-oxo-, propyl ester
- CAS REGISTRY NUMBER :
- 587-61-1
- BEILSTEIN REFERENCE NO. :
- 0206829
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C10-H11-I2-N-O3
- MOLECULAR WEIGHT :
- 447.02
- WISWESSER LINE NOTATION :
- T6N DVJ A1VO3 CI EI
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >18 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,166,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Vascular - acute arterial occlusion
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,166,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 26,921,1984
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3,5-Diiodo-4-pyridone-N-acetic acid propyl ester |
| propyliodone |
| Bronchodiagnostin |
| Bronkhodiagnostin |
| Dionosil |
| Propiodone |
| Diostril |
| Brosombra |
