Introduction：Basic information about CAS 133812-16-5|(E/Z)-Locostatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (E/Z)-Locostatin |
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| CAS Number | 133812-16-5 | Molecular Weight | 245.27400 |
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| Density | 1.205g/cm3 | Boiling Point | 351ºC at 760mmHg |
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| Molecular Formula | C14H15NO3 | Melting Point | 84-88ºC(lit.) |
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| MSDS | / | Flash Point | 166.1ºC |
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Names
| Name | (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one |
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| Synonym | More Synonyms |
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(E/Z)-Locostatin BiologicalActivity
| Description | (E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | RKIP[3] |
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| References | [1]. Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. [2]. Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. [3]. Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998. |
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Chemical & Physical Properties
| Density | 1.205g/cm3 |
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| Boiling Point | 351ºC at 760mmHg |
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| Melting Point | 84-88ºC(lit.) |
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| Molecular Formula | C14H15NO3 |
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| Molecular Weight | 245.27400 |
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| Flash Point | 166.1ºC |
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| Exact Mass | 245.10500 |
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| PSA | 46.61000 |
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| LogP | 2.09050 |
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| Vapour Pressure | 4.22E-05mmHg at 25°C |
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| Index of Refraction | 1.57 |
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| InChIKey | UTZAFVPPWUIPBH-LBPRGKRZSA-N |
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| SMILES | CC=CC(=O)N1C(=O)OCC1Cc1ccccc1 |
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Safety Information
Synonyms
