Introduction：Basic information about CAS 134036-52-5|(E/Z)-AG490, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (E/Z)-AG490 |
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| CAS Number | 134036-52-5 | Molecular Weight | 294.30500 |
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| Density | 1.337g/cm3 | Boiling Point | 615.2ºC at 760mmHg |
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| Molecular Formula | C17H14N2O3 | Melting Point | 215ºC |
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| MSDS | / | Flash Point | 325.9ºC |
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Names
| Name | ag 490 |
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| Synonym | More Synonyms |
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(E/Z)-AG490 BiologicalActivity
| Description | (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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Chemical & Physical Properties
| Density | 1.337g/cm3 |
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| Boiling Point | 615.2ºC at 760mmHg |
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| Melting Point | 215ºC |
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| Molecular Formula | C17H14N2O3 |
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| Molecular Weight | 294.30500 |
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| Flash Point | 325.9ºC |
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| Exact Mass | 294.10000 |
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| PSA | 93.35000 |
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| LogP | 2.71208 |
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| InChIKey | TUCIOBMMDDOEMM-UHFFFAOYSA-N |
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| SMILES | N#CC(=Cc1ccc(O)c(O)c1)C(=O)NCc1ccccc1 |
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| Storage condition | −20°C |
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| Water Solubility | ethanol: 5 mg/mL |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 1 |
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Synonyms
