Introduction：Basic information about CAS 39011-92-2|Specnuezhenide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Specnuezhenide |
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| CAS Number | 39011-92-2 | Molecular Weight | 686.655 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 893.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C31H42O17 | Melting Point | / |
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| MSDS | / | Flash Point | 282.0±27.8 °C |
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Names
| Name | Nuezhenide |
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| Synonym | More Synonyms |
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Specnuezhenide BiologicalActivity
| Description | Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>WntResearch Areas >>Inflammation/Immunology |
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| In Vitro | Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2]. |
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| References | [1]. Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700. [2]. Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 893.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C31H42O17 |
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| Molecular Weight | 686.655 |
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| Flash Point | 282.0±27.8 °C |
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| Exact Mass | 686.242188 |
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| PSA | 260.59000 |
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| LogP | -0.31 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.636 |
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| InChIKey | STKUCSFEBXPTAY-RDXZJVGFSA-N |
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| SMILES | CC=C1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CC(=O)OCC1OC(OCCc2ccc(O)cc2)C(O)C(O)C1O |
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Safety Information
| Safety Phrases | 24/25 |
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| HS Code | 29389090 |
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Synonyms
| Specnuezhenide |
| 2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside |
| β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate] |
| β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate] |
| 2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside |
| Specneuzhenide |
