Introduction：Basic information about CAS 160498-00-0|Bisandrographolide A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bisandrographolide A |
|---|
| CAS Number | 160498-00-0 | Molecular Weight | 664.868 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 832.6±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C40H56O8 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 252.3±27.8 °C |
|---|
Names
| Name | Bisandrographolide A |
|---|
| Synonym | More Synonyms |
|---|
Bisandrographolide A BiologicalActivity
| Description | Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2]. |
|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Inflammation/Immunology |
|---|
| Target | TRPV4 channel[1]. |
|---|
| References | [1]. Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183. [2]. Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 832.6±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C40H56O8 |
|---|
| Molecular Weight | 664.868 |
|---|
| Flash Point | 252.3±27.8 °C |
|---|
| Exact Mass | 664.397522 |
|---|
| PSA | 133.52000 |
|---|
| LogP | 3.82 |
|---|
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
|---|
| Index of Refraction | 1.596 |
|---|
| InChIKey | WQHWOZANSOUSAY-LZBAHHAZSA-N |
|---|
| SMILES | C=C1CCC2C(C)(CO)C(O)CCC2(C)C1C=CC1=CC(C(CC2C(=C)CCC3C(C)(CO)C(O)CCC23C)C2=CCOC2=O)OC1=O |
|---|
Synonyms
| 2(5H)-Furanone, 5-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]-1-(2,5-dihydro-2-oxo-3-furanyl)ethyl]-3-[(E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- |
| 5-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]-1-(2-oxo-2,5-dihydro-3-furanyl)ethyl}-3-{(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]vinyl}-2(5H)-furanone |
