Introduction：Basic information about CAS 77275-70-8|[D-Pro2,D-Phe7,D-Trp9]-Substance P, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | [D-Pro2,D-Phe7,D-Trp9]-Substance P |
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| CAS Number | 77275-70-8 | Molecular Weight | 1476.79000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C72H105N19O13S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | [D-Pro2,D-Phe7,D-Trp9]-Substance P |
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| Synonym | More Synonyms |
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[D-Pro2,D-Phe7,D-Trp9]-Substance P BiologicalActivity
| Description | [D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | Substance P[2] |
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| In Vitro | [D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein[1]. |
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| In Vivo | [D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2]. |
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| References | [1]. Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8. [2]. Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6. |
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Chemical & Physical Properties
| Molecular Formula | C72H105N19O13S |
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| Molecular Weight | 1476.79000 |
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| Exact Mass | 1475.79000 |
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| PSA | 557.72000 |
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| LogP | 6.28670 |
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| InChIKey | DJTXGXBJAUKOBG-YHWCEVJTSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(N)=O |
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Synonyms
| substance P,Pro(2)-Phe(7)-Trp(9) |
| Substance P,(D-Pro2,D-Phe7,D-Trp9) |
| ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2 |
| (D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P) |
| (D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P |
| H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2 |
