CAS 109212-72-8|(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B

Introduction：Basic information about CAS 109212-72-8|(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (D-Pro2,D-Trp6.8,Nle10)-Neurokinin B BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B
CAS Number	109212-72-8	Molecular Weight	1326.50000
Density	/	Boiling Point	/
Molecular Formula	C₆₇H₈₇N₁₅O₁₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	[D-Pro2, D-Trp6,8, Nle10]-Neurokinin B,DpHDFwVwL-Nle-NH2
Synonym	More Synonyms

(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B BiologicalActivity

Description	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
In Vivo	在大鼠中，(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) 显着减少 Substance P- 和 Neurokinin B-，但不减少乙酰胆碱或 Neurokinin A 诱导的流涎。(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 可将麻醉大鼠的血压降低 35% 至 40%[2]。
References	[1]. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. [2]. C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6.

Chemical & Physical Properties

Molecular Formula	C₆₇H₈₇N₁₅O₁₄
Molecular Weight	1326.50000
Exact Mass	1325.66000
PSA	457.08000
LogP	5.63230
InChIKey	SBSGAKKSUHYFOA-KDICMADCSA-N
SMILES	CCCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCCN1C(=O)C(N)CC(=O)O)C(C)C)C(N)=O

Synonyms

ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2

(D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B

(D-Pro2,D-Trp6

DPHDFWVWL-NLE-NH2

H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2

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