CAS 77128-69-9|(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)

Introduction：Basic information about CAS 77128-69-9|(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
CAS Number	77128-69-9	Molecular Weight	880.064
Density	1.3±0.1 g/cm3	Boiling Point	1291.2±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₆₁N₉O₉S	Melting Point	/
MSDS	/	Flash Point	734.7±34.3 °C

Names

Name	G Substance P (5-11)
Synonym	More Synonyms

(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) BiologicalActivity

Description	[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
In Vivo	[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 µg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢[1]。 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 µg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复[2]。 Animal Model: Male Sprague-Dawley rats (300-350 g)[1]. Dosage: 2 µg/side Administration: Inject into the ventral tegmental area; single Result: Selectively activated mesolimbic and mesocortical dopamine metabolism. Animal Model: Male Wistar rats (300-350 g)[2]. Dosage: 0.5, 1.5, 3 µg/side Administration: Inject into the ventral tegmental area; single Result: Significantly increased locomotor activity when at 3 µg/side.
References	[1]. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. [2]. Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. [3]. Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	1291.2±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₆₁N₉O₉S
Molecular Weight	880.064
Flash Point	734.7±34.3 °C
Exact Mass	879.431274
PSA	297.60000
LogP	1.66
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.580
InChIKey	IEEBRBMEXFNVKU-CVUOCSEZSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(N)=O

Synonyms

5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide

PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5-11

PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2

DiMe-C7

PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2

SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11

L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-

[GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11)

GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2

[pGlu5,MePhe8,Sar9]substance P(5-11)

(PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11)

substance P (5-11),pGlu(5)-MePhe(8)-MeGly(9)

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