Introduction：Basic information about CAS 79775-19-2|(Pyr6,Pro9)-Substance P (6-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Pyr6,Pro9)-Substance P (6-11) |
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| CAS Number | 79775-19-2 | Molecular Weight | 850.87400 |
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| Density | 1.255g/cm3 | Boiling Point | 1189.4ºC at 760 mmHg |
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| Molecular Formula | C39H50N10O12 | Melting Point | / |
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| MSDS | / | Flash Point | 673.1ºC |
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Names
| Name | [Pyr6,Pro9]-Substance P (6-11) |
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| Synonym | More Synonyms |
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(Pyr6,Pro9)-Substance P (6-11) BiologicalActivity
| Description | Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor |
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| Target | Kd: 0.55 ± 0.03 nM (NK1 receptor)[1] |
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| In Vitro | Septide increases inositol phosphate levels (4-6-fold) in NK1 receptor expressed CHO cells[2]. |
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| References | [1]. Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6. [2]. Pradier L, Mayaux JF, et al. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93. |
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Chemical & Physical Properties
| Density | 1.255g/cm3 |
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| Boiling Point | 1189.4ºC at 760 mmHg |
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| Molecular Formula | C39H50N10O12 |
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| Molecular Weight | 850.87400 |
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| Flash Point | 673.1ºC |
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| Exact Mass | 850.36100 |
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| PSA | 357.57000 |
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| Index of Refraction | 1.587 |
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| InChIKey | UUZURPUIMYJOIL-JNRWAQIZSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C1CCC(=O)N1)C(N)=O |
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Synonyms
| [GLP6,PRO9] SUBSTANCE P (6-11) |
| PYR-PHE-PHE-PRO-LEU-MET-NH2 |
| SEPTIDE |
| PYR-FFPLM |
| [pGlu6,Pro9]substance P-(6-11) |
| [Glp6,L-Pro9]SP(6-11) |
| PGLU-PHE-PHE-PRO-LEU-MET-NH2 |
| (PYR6,PRO9)-SUBSTANCE P (6-11) |
| GLP-PHE-PHE-PRO-LEU-MET-NH2 |
| [pGlu6,Pro9]subustance P(6-11) |
