CAS 338-98-7|Predef

Introduction：Basic information about CAS 338-98-7|Predef, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Predef BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Predef
CAS Number	338-98-7	Molecular Weight	420.471
Density	1.3±0.1 g/cm3	Boiling Point	576.5±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₉FO₆	Melting Point	244-246 °C
MSDS	/	Flash Point	302.5±30.1 °C

Names

Name	Isoflupredone Acetate
Synonym	More Synonyms

Predef BiologicalActivity

Description	Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In Vitro	Isoflupredone acetate (10-4, 10-7, or 10-10 M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7 M and 10-10 M) than the high concentration (10-4 M)[1].
In Vivo	Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275)[2]. Animal Model: 96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2] Dosage: 0.05 mg/kg Administration: i.m.; on days 2 and 4 after the challenge Result: Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers.Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	576.5±50.0 °C at 760 mmHg
Melting Point	244-246 °C
Molecular Formula	C₂₃H₂₉FO₆
Molecular Weight	420.471
Flash Point	302.5±30.1 °C
Exact Mass	420.194824
PSA	100.90000
LogP	2.46
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.577
InChIKey	ZOCUOMKMBMEYQV-GSLJADNHSA-N
SMILES	CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3970000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate

CAS REGISTRY NUMBER :: 338-98-7

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H29-F-O6

MOLECULAR WEIGHT :: 420.52

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 120 ug/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

(11b)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl Acetate

21-Acetoxy-9-fluoro-11β,17-dihydroxypregna-1,4-diene-3,20-dione

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI)

(11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate

[2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

9-Fluoroprednisolone 21-acetate

Pregna-1,4-diene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate

9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-

Predef

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