Introduction：Basic information about CAS 131986-45-3|Xanomeline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Xanomeline |
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| CAS Number | 131986-45-3 | Molecular Weight | 281.41700 |
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| Density | 1.101 g/cm3 | Boiling Point | 397ºC at 760 mmHg |
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| Molecular Formula | C14H23N3OS | Melting Point | / |
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| MSDS | / | Flash Point | 193.9ºC |
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Names
| Name | xanomeline |
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| Synonym | More Synonyms |
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Xanomeline BiologicalActivity
| Description | Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease |
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| Target | M1/M4[1][2] |
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| In Vitro | Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1]. |
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| In Vivo | Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3]. Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile.Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3]. Animal Model: Male Cebus apella monkeys Dosage: 0.5~3 mg/kg Administration: S.c.; 1~3 hours Result: Induced salivation and vomiting in some monkeys. |
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| References | [1]. Kreir M, et al. Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. Eur J Pharmacol. 2019;858:172474 [2]. Shekhar A, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165(8):1033-1039. [3]. Andersen MB, et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology. 2003;28(6):1168-1175. |
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Chemical & Physical Properties
| Density | 1.101 g/cm3 |
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| Boiling Point | 397ºC at 760 mmHg |
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| Molecular Formula | C14H23N3OS |
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| Molecular Weight | 281.41700 |
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| Flash Point | 193.9ºC |
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| Exact Mass | 281.15600 |
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| PSA | 66.49000 |
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| LogP | 3.15400 |
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| Appearance of Characters | off-white |
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| Vapour Pressure | 1.64E-06mmHg at 25°C |
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| Index of Refraction | 1.537 |
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| InChIKey | JOLJIIDDOBNFHW-UHFFFAOYSA-N |
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| SMILES | CCCCCCOc1nsnc1C1=CCCN(C)C1 |
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| Storage condition | 2-8°C |
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| Water Solubility | H2O: soluble10mg/mL, clear (warmed) |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole |
| 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole |
